| Aerolíneas | Destino |
|---|---|
| AeroGal | Baltra, Bogotá, Cuenca, Guayaquil, Lima, Manta, Medellín-Córdova, Coca, Lago Agrio, San Cristóbal |
| American Airlines | Miami |
| Avianca | Bogotá |
| Copa Airlines | Panama City |
| Copa Airlines Colombia | Bogotá |
| Delta Air Lines | Atlanta |
| Iberia | Madrid |
| KLM | Amsterdam |
| Lacsa | San José |
| LAN Airlines | Miami, Santiago de Chile |
| LAN Ecuador | Baltra, Buenos Aires-Ezeiza, Cuenca, Guayaquil, Manta, Miami, San Cristóbal, Santiago de Chile |
| LAN Perú | Bogotá (a partir de Julio 1, 2013), Cali, Lima, Medellín-Córdova |
| SAEREO | Macas |
| TACA Airlines | San Salvador |
| TACA Peru | Lima |
| TAME | Baltra, Bogotá, Cali, Caracas, Coca, Cuenca, Esmeraldas, Guayaquil, Havana, Lago Agrio, Lima, Loja, Manta, Macas, New York-JFK (begins June 6, 2013), Panama City, Salinas, São Paulo-Guarulhos, San Cristóbal, Santa Rosa, Tena, Tulcan, Charter:Cartagena, Curaçao, Montego Bay, Punta Cana, San Andrés, Varadero |
| United Airlines | Houston-Intercontinental |
Aún no hay rutas registradas para este aeropuerto.


